Steroid Effects PermanentLearn about the permanent effects of testosterone therapy and anabolic steroids.
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Steroids, permanent. A bodybuilder uses steroids. He gains size. His body is thick and big. But when he stops injecting steroids, will he lose his muscle mass? This is a concern.

Permanent effects. Steroids have permanent effects. Some changes persist long after the usage of testosterone is stopped. We find permanent changes in muscle fiber composition.

Testosterone Injections

Male rats. Testosterone increases aggression in male rats even after stopped. Some effects are temporary. Some are long-term or even permanent.

Muscle mass research. Research has found that the muscles of powerlifters who have used anabolic steroids are different. This applies even to lifters who have stopped using the steroids.

Quote The number of myonuclei/fiber and the proportion of central nuclei were significantly higher in the [powerlifters who used anabolic steroids] group.

Skeletal muscle morphology

Research, continued. The muscle fiber areas of the men who used anabolic steroids were larger. The group of powerlifters includes men who had ever (in their lives) used steroids.

Control The group of men who were compared had never used steroids. So the study determined the long-term effects of AAS.

Quote Similar results were seen in the trapezius muscle... in [the trapezius muscle] the proportion of fibers expressing developmental myosin isoforms was higher in the [powerlifters who used anabolic steroids] group compared to the [other] group (Skeletal muscle morphology).

Research, traps. AAS affect certain muscle groups more than others. The trapezius muscle had more fibers in people who used anabolic steroids. But it also had fibers that were different.

Quote The initial effects from [anabolic steroids] appear to be maintained for several years (Skeletal muscle morphology).

Analysis. Once an athlete takes these performance-enhancing supplements, the changes persist. The muscle fiber area changes. The composition of the muscles changes.

And This lasts even after the steroids are discontinued. In effect the muscular gains from steroid use are permanent.

Trapezius. Muscles respond differently to exercise and anabolic steroids. The permanent muscle gains from anabolic steroids may be greater in muscles that respond the most.

Neck, traps The neck and trapezius muscles have the most androgen receptors. This could explain their response to steroids.

The expression of androgen receptors

A question. Neck and trapezius muscles respond the most to anabolic steroid use. Could steroid users be detected by the proportional sizes of the trapezius and neck muscles?

Behavior. How does testosterone therapy affect behavior in the long-term? Does it cause only temporary changes or long-term, even permanent changes?

One study This study was done on rats. Some rats were given testosterone injections. These were muscular, impressive rats.

Behavior, continued. The rats given testosterone had more aggression when provoked. And after the rats were no longer being given testosterone, they still had higher levels of aggression.

Long-term effects of steroid exposure

Behavior, analysis. Some changes occur in the brain when testosterone is used. The results of the study indicate that these changes could be long-term or even permanent.

So People who have taken anabolic steroids—even for medical purposes—may have permanently increased levels of aggression.

Balance. Testosterone injections can affect the brain in other ways. The balancing mechanism can be affected. One report describes a man who used anabolic steroids.

And After usage of testosterone the man developed vertigo. This effect persisted.

Quote The moment of appearance and long-lasting vertigo as well as the results of laboratory examinations indicate a poststeroid permanent disorder of the central part of the equilibrium organ. Such a diagnosis seems to be most probable here.

Poststeroid balance disorder case report

Effects, notes. The effects of testosterone therapy are profound. Many side effects, even those that are not common, can occur. And many of these side effects are not short-term.

Thus Some effects persist for months and years. Some are even permanent, lasting throughout a person's remaining life.

Adverse effects. These are side effects. One report from Clinical Chemistry describes that scientific evidence finally supports testosterone and its muscle-building properties.

And It notes that the adverse effects of testosterone are reversible—except in women and children.

Quote New evidence supports the view that supraphysiological doses of anabolic steroids do have a definite, positive effect on muscle size and muscle strength.... Most of the adverse effects of AAS are reversible but some are permanent, particularly in women and children.

Endocrine aspects of anabolic steroids

Hormone changes. One study has found that the suppression of a man's hormones does not go away immediately after stopping testosterone injections.

Instead It takes up to one year to normalize. And cholesterol levels take six months to return to normal after testosterone is stopped.

Quote Some individuals had a sustained suppression of LH and FSH for a period of 1 year... the cholesterol profile was normalized within 6 [months]. The long-term consequences of these findings remain to be established.

Long-term perturbation of endocrine parameters

Not permanent. Hormone changes are long-term but not permanent. The hormone levels of LH and FSH return to normal. So too did their cholesterol levels. Their hormone profiles recovered.

Short-term Some effects of testosterone replacement therapy are short-term. These side effects include acne and testicular atrophy.


Summary. All people have some level of anabolic steroids in their bodies. They are part of life in both men and women. Drugs that contain synthetic testosterone have further effects.

When we take steroids, our bodies change. It affects muscle composition permanently. It changes behavior permanently. It can cause long-term side effects.

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